Revised 2015

A swelling in the neck due to an enlarged thyroid gland is called a goitre. Nodules are lumps in the thyroid gland. Most are harmless but you should arrange an appointment with your doctor as soon as you find a lump or swelling.

Main causes of enlargement of the thyroid

  • The main cause is unknown but thyroid nodules and enlargement are more common in women than men
  • Women often develop thyroid enlargement during pregnancy and the menopause
  • Diffuse enlargement is often caused by autoimmune thyroid conditions such as Hashimoto's thyroiditis and Graves' disease and can be associated with a change in thyroid function
  • Iodine deficiency is the most common cause worldwide

Main types of thyroid nodules and swellings

  • Single thyroid nodule (solitary nodule)
  • Multiple thyroid nodules (multinodular goitre) - sometimes caused by an over-active thyroid
  • Diffuse goitre - often found in Hashimoto’s thyroiditis and Graves’ disease (autoimmune thyroid disorders)
  • Retrosternal goitre - thyroid develops lower down behind the breastbone (often a multi-nodular goitre)

More about single nodules

  • Colloid and hyperplastic nodules – benign lumps, which can be solitary or part of a multinodular goitre
  • Thyroid adenoma - a solid benign lump
  • Thyroid cyst - swelling that contains fluid
  • Thyroid cancer - rare and has a high cure rate


Some of the following investigations may be necessary:

  • Blood tests - check thyroid hormone levels
  • Ultrasound scan - checks size and shape of thyroid
  • Fine needle aspiration cytology (FNAC) - removes cells from the thyroid for examination
  • X-rays - to check position of windpipe (trachea)
  • Nuclear medicine scan - checks size, shape and whether over-active (‘hot’) or under-active (‘cold’)


This may involve one or several of the following:

  • Usually reassurance is only required
  • Surgery
  • Radioactive iodine
  • Antithyroid drugs
  • Levothyroxine tablets

It is well recognised that thyroid problems often run in families and if family members are unwell they should be encouraged to discuss with their own GP whether thyroid testing is warranted.

If you have questions or concerns about your thyroid disorder, you should talk to your doctor or specialist as they will be best placed to advise you. You may also contact the British Thyroid Foundation for further information and support, or if you have any comments about the information contained in this leaflet.

The British Thyroid Foundation
The British Thyroid Foundation is a registered charity: England and Wales No 1006391, Scotland SC046037

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Endorsed by:

The British Thyroid Association - medical professionals encouraging the highest standards in patient care and research

The British Association of Endocrine and Thyroid Surgeons - the representative body of British surgeons who have a specialist interest in surgery of the endocrine glands (thyroid, parathyroid and adrenal)

First issued: 2008
Revised: 2010, 2011, 2015
Our literature is reviewed every two years and revised if necessary.

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